KMO Antibody (PACO27833)
- SKU:
- PACO27833
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KMO Antibody (PACO27833)
If you are interested in studying the role of CD300A in immune regulation and its implications in various diseases, the CD300A Polyclonal Antibody from Assay Genie is an essential tool for your research. With its high reactivity to human samples and validation for Western blot applications, this antibody allows for precise detection and analysis of CD300A protein in different cell types.
By providing valuable insights into the function of CD300A, this antibody is a valuable asset for immunology and cancer research. Don't miss out on the opportunity to advance your understanding of immune regulation with the CD300A Polyclonal Antibody from Assay Genie.
| Antibody Name: | KMO Antibody (PACO27833) |
| Antibody SKU: | PACO27833 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Kynurenine 3-monooxygenase protein (1-486AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO27833 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO27833 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid, may also affect NMDA receptor signaling in pancreatic β cells, osteoblasts, myocardial cells, and the gastrointestinal tract. |
| Synonyms: | Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase), KMO |
| UniProt Protein Function: | KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Mitochondrial; EC 1.14.13.9; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q42-q44Cellular Component: cytosol; mitochondrial outer membraneMolecular Function: FAD binding; kynurenine 3-monooxygenase activity; NAD(P)H oxidase activityBiological Process: NAD metabolic process; response to salt stress; tryptophan catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O15229 |
| NCBI GenInfo Identifier: | 126302562 |
| NCBI Gene ID: | 8564 |
| NCBI Accession: | O15229.2 |
| UniProt Secondary Accession: | O15229,Q5SY07, Q5SY08, Q5SY09, A2A2U8, A2A2U9, A2A2V0 |
| UniProt Related Accession: | O15229 |
| Molecular Weight: | 51,682 Da |
| NCBI Full Name: | Kynurenine 3-monooxygenase |
| NCBI Synonym Full Names: | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
| NCBI Official Symbol: | KMOÂ Â |
| NCBI Official Synonym Symbols: | dJ317G22.1Â Â |
| NCBI Protein Information: | kynurenine 3-monooxygenase |
| UniProt Protein Name: | Kynurenine 3-monooxygenase |
| UniProt Synonym Protein Names: | Kynurenine 3-hydroxylase |
| Protein Family: | |
| UniProt Gene Name: | KMOÂ Â |
| UniProt Entry Name: | KMO_HUMAN |
| Antibodies | ELISA Kits |
| KMO Antibody (PACO10149) | Human Kynurenine 3-monooxygenase (KMO) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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