The KMO Polyclonal Antibody (PACO10149) is a valuable tool for researchers studying the KMO protein, an essential enzyme in the kynurenine pathway involved in the metabolism of tryptophan. This antibody is produced in rabbits and demonstrates high reactivity with human samples, making it suitable for use in Western blot applications. By binding to the KMO protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in neuroscience, immunology, and cancer research.
The KMO protein plays a crucial role in immune regulation and neurotransmitter synthesis, making it an intriguing target for research into neurodegenerative diseases, psychiatric disorders, and cancer. Understanding the function of KMO can provide valuable insights into the pathogenesis of these conditions and may lead to the development of novel therapeutic approaches targeting the kynurenine pathway. The KMO Polyclonal Antibody offers researchers a reliable tool for exploring the role of KMO in health and disease.
KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Mitochondrial; EC 1.14.13.9; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q42-q44Cellular Component: cytosol; mitochondrial outer membraneMolecular Function: FAD binding; kynurenine 3-monooxygenase activity; NAD(P)H oxidase activityBiological Process: NAD metabolic process; response to salt stress; tryptophan catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
