The KLRK1 Polyclonal Antibody (CAB11964) is a valuable tool for researchers studying KLRK1, a cell surface receptor involved in immune surveillance and recognition of abnormal cells such as tumor cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By binding to the KLRK1 protein, this antibody allows for the detection and analysis of KLRK1 expression in various cell types, facilitating investigations in immunology and cancer research.
KLRK1, also known as NKG2D, plays a vital role in the immune response by activating natural killer (NK) cells and cytotoxic T cells to eliminate target cells expressing stress-induced ligands. Its involvement in immune surveillance makes it a promising target for studies on cancer immunotherapy, autoimmune diseases, and infectious diseases. Understanding the function of KLRK1 is essential for developing therapeutic strategies that enhance immune responses against cancer cells and infected cells while preventing autoimmunity.
Product Name:
KLRK1 Rabbit Polyclonal Antibody
SKU:
CAB11964
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KLRK1 (NP_031386.2).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
25kDa
Observed MW:
Refer to figures
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Purification Method:
Affinity purification
Gene ID:
22914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using KLRK1 Rabbit pAb (CAB11964) at dilution of 1:100. Blue: DAPI for nuclear staining.
