KLRG1 Antibody (PACO39298)
- SKU:
- PACO39298
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
KLRG1 Antibody (PACO39298)
The KLRG1 Polyclonal Antibody (PACO39298) is a valuable tool for researchers studying KLRG1, a cell surface receptor involved in regulating immune responses. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the KLRG1 protein, this antibody enables the detection and analysis of KLRG1 in various cell types, making it well-suited for studies in immunology and cancer research.
KLRG1, also known as killer cell lectin-like receptor G1, plays a critical role in the immune system by modulating the activity of immune cells. Its involvement in immune regulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of KLRG1 is essential for developing novel therapies that target or manipulate immune responses in these pathological contexts.
| Antibody Name: | KLRG1 Antibody (PACO39298) |
| Antibody SKU: | PACO39298 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Killer cell lectin-like receptor subfamily G member 1 protein (60-195AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO39298 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO39298 at dilution of 1:100. |
| Background: | Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. |
| Synonyms: | Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen), KLRG1, CLEC15A MAFA MAFAL |
| UniProt Protein Function: | KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: plasma membrane; integral to membraneMolecular Function: receptor activity; carbohydrate bindingBiological Process: regulation of immune response; cell surface receptor linked signal transduction; innate immune response; cellular defense response; inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96E93 |
| NCBI GenInfo Identifier: | 47717096 |
| NCBI Gene ID: | 10219 |
| NCBI Accession: | NP_005801.3 |
| UniProt Secondary Accession: | Q96E93,O43198, O75613, B7ZAM2 |
| UniProt Related Accession: | Q96E93 |
| Molecular Weight: | 21,206 Da |
| NCBI Full Name: | killer cell lectin-like receptor subfamily G member 1 |
| NCBI Synonym Full Names: | killer cell lectin-like receptor subfamily G, member 1 |
| NCBI Official Symbol: | KLRG1Â Â |
| NCBI Official Synonym Symbols: | 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKEÂ Â |
| NCBI Protein Information: | killer cell lectin-like receptor subfamily G member 1; MAFA-like receptor; ITIM-containing receptor MAFA-L; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; mast cell function-associated antigen (ITIM-containing) |
| UniProt Protein Name: | Killer cell lectin-like receptor subfamily G member 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen |
| Protein Family: | |
| UniProt Gene Name: | KLRG1Â Â |
| UniProt Entry Name: | KLRG1_HUMAN |
| Antibodies |
| KLRG1 Antibody (PACO10148) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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