The KLRG1 Monoclonal Antibody (PACO10148) is an essential tool for research involving KLRG1, a cell surface receptor found on T cells and natural killer cells. This antibody, produced through a unique monoclonal antibody technology, is highly specific to human KLRG1 and is validated for use in various applications, including flow cytometry and immunohistochemistry.KLRG1, also known as killer cell lectin-like receptor G1, is known to be a marker for terminally differentiated effector cells with limited proliferative capacity. Its expression levels have been linked to T cell exhaustion and dysfunction in chronic infections and cancer.
By using the KLRG1 Monoclonal Antibody, researchers can precisely detect and quantify KLRG1 expression in different cell populations, aiding in the characterization of immune responses in various disease states.The KLRG1 Monoclonal Antibody (PACO10148) opens up new possibilities for studying the role of KLRG1 in immune regulation, anti-tumor immunity, and autoimmune diseases. Its high specificity and reliability make it an invaluable tool for advancing our understanding of immune responses and developing novel therapeutic strategies.
killer cell lectin-like receptor subfamily G, member 1;KLRG1;2F1;CLEC15A;MAFA;MAFA-2F1;MAFA-L;MAFA-LIKE;MGC13600 ;
UniProt Protein Function:
KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: plasma membrane; integral to membraneMolecular Function: receptor activity; carbohydrate bindingBiological Process: regulation of immune response; cell surface receptor linked signal transduction; innate immune response; cellular defense response; inflammatory response
UniProt Protein Details:
NCBI Summary:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
