The KLRD1 Polyclonal Antibody (PAC019915) is a valuable tool for researchers studying KLRD1, a cell surface receptor involved in immune regulation and cell signaling pathways. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the KLRD1 protein, this antibody allows for the detection and analysis of KLRD1 in various cell types, making it an excellent choice for studies in immunology and cancer research.KLRD1, also known as CD94, is a key player in the modulation of immune responses, particularly in NK cell function and immune surveillance.
Its role in immune regulation makes it a promising target for research into diseases such as cancer, viral infections, and autoimmune disorders. Understanding the function of KLRD1 is essential for the development of therapies that leverage the immune system against these conditions. Overall, the KLRD1 Polyclonal Antibody is a reliable tool for investigating the role of KLRD1 in immune regulation and disease pathogenesis, providing valuable insights into potential therapeutic interventions.
Antibody Name:
KLRF1 Antibody (PACO19915)
Antibody SKU:
PACO19915
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human KLRF1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19915(KLRF1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19915(KLRF1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release
Synonyms:
killer cell lectin-like receptor subfamily F, member 1
UniProt Protein Function:
KLRF1: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: membrane; integral to plasma membraneMolecular Function: transmembrane receptor activity; MHC class I receptor activity; carbohydrate bindingBiological Process: cell surface receptor linked signal transduction
UniProt Protein Details:
NCBI Summary:
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
