The KLRD1 Polyclonal Antibody (CAB12698) is a vital tool for researchers studying KLRD1, also known as CD94, an important cell surface receptor involved in immune regulation and recognition. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the KLRD1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in immunology and cancer research.KLRD1, a member of the C-type lectin-like receptor family, plays a crucial role in immune surveillance and response. It is involved in the recognition of HLA-E molecules, which are essential for the regulation of immune responses to infected or stressed cells.
The presence of KLRD1 on natural killer cells and T cells highlights its significance in immune function and potential as a therapeutic target for diseases such as cancer, viral infections, and autoimmune disorders.Understanding the function and regulation of KLRD1 is essential for advancing research in immunology and developing innovative therapies that target immune checkpoints. The KLRD1 Polyclonal Antibody (CAB12698) provides researchers with a reliable tool to explore the role of KLRD1 in immune modulation and disease pathogenesis, paving the way for groundbreaking discoveries in the field of immunotherapy.
Product Name:
KLRD1 Rabbit Polyclonal Antibody
SKU:
CAB12698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 32-179 of human KLRD1 (NP_002253.2).
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3824
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using KLRD1 Rabbit pAb (CAB12698) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
