| UniProt Protein Function: | KLRC3: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: integral to membraneMolecular Function: transmembrane receptor activity; carbohydrate bindingBiological Process: cellular defense response; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q07444 |
| NCBI GenInfo Identifier: | 75709175 |
| NCBI Gene ID: | 3823 |
| NCBI Accession: | NP_002252 |
| UniProt Secondary Accession: | Q07444 |
| UniProt Related Accession: | Q07444 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | NKG2-E type II integral membrane protein isoform E |
| NCBI Synonym Full Names: | killer cell lectin like receptor C3 |
| NCBI Official Symbol: | KLRC3Â Â |
| NCBI Official Synonym Symbols: | NKG2E; NKG2-EÂ Â |
| NCBI Protein Information: | NKG2-E type II integral membrane protein |
| UniProt Protein Name: | NKG2-E type II integral membrane protein |
| UniProt Synonym Protein Names: | NK cell receptor E; NKG2-E-activating NK receptor |
| Protein Family: | NKG2-E type II integral membrane protein |
| UniProt Gene Name: | KLRC3Â Â |
| UniProt Entry Name: | NKG2E_HUMAN |
