The KLRC1 Polyclonal Antibody (CAB1233) is a valuable tool for researchers studying KLRC1, a cell surface protein involved in immune regulation and natural killer (NK) cell activity. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the KLRC1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.KLRC1, also known as NKG2A, is a key player in regulating NK cell function and mediating immune responses. Its role in recognizing abnormal or infected cells and initiating immune responses makes it a crucial target for research on diseases like cancer, viral infections, and autoimmune disorders.
By understanding the function of KLRC1, researchers can develop new therapies that enhance immune responses or target specific cells for destruction.Overall, the KLRC1 Polyclonal Antibody (CAB1233) is a valuable resource for researchers delving into the complex interactions of the immune system and identifying potential targets for therapeutic interventions. Its high specificity and reliability make it a trusted tool for advancing our understanding of immune regulation and developing new treatments for a variety of diseases.
Product Name:
KLRC1 Rabbit Polyclonal Antibody
SKU:
CAB1233
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 96-215 of human KLRC1 (NP_015567.1).
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
3821
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KLRC1 antibody (CAB1233) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
