The KLRB1 Polyclonal Antibody (CAB6928) is a crucial tool for researchers studying KLRB1, a cell surface molecule involved in immune regulation and natural killer cell activity. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. It specifically binds to the KLRB1 protein, allowing for precise detection and analysis in diverse cell types, making it an invaluable asset for studies in immunology and cancer research.KLRB1, also known as CD161, is a receptor expressed on natural killer cells and subsets of T cells, functioning in immune surveillance and response against pathogens and tumor cells.
Its role in regulating immune cell activity highlights its importance in understanding immune function and developing therapeutic strategies for diseases like cancer and autoimmune disorders. By targeting KLRB1, researchers can gain insights into immune responses and potentially identify new approaches for treating immune-related conditions.
Product Name:
KLRB1 Rabbit Polyclonal Antibody
SKU:
CAB6928
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_002249.1).
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus.
Purification Method:
Affinity purification
Gene ID:
3820
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver using KLRB1 Rabbit pAb (CAB6928) at 1:3000 dilution incubated overnight at 4℃.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
