The Klotho Polyclonal Antibody (CAB12028) is a valuable tool for researchers studying Klotho, a transmembrane protein involved in regulating aging and multiple physiological processes. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of Klotho protein in various cell types.Klotho is known for its role in extending lifespan and protecting against age-related diseases, making it a promising target for research in the fields of longevity, metabolic disorders, and age-related conditions.
By understanding the function and regulation of Klotho, researchers can uncover new insights into aging mechanisms and potentially develop novel therapeutic strategies for age-related diseases.With its high reactivity and specificity, the Klotho Polyclonal Antibody is an essential tool for scientists investigating the physiological roles and mechanisms of action of Klotho in various biological processes, making it ideal for studies in aging, metabolism, and disease research.
Product Name:
KL Rabbit Polyclonal Antibody
SKU:
CAB12028
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KL (NP_004786.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
116kDa
Observed MW:
65kDa, 120kDa
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Purification Method:
Affinity purification
Gene ID:
9365
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KL Rabbit pAb (CAB12028) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
