The KLLN Polyclonal Antibody (PAC019913) is a valuable tool for researchers studying the KLLN protein, a tumor suppressor involved in regulating cell growth and proliferation. This antibody is produced in rabbits and demonstrates high reactivity with human samples, making it suitable for Western blot applications. By specifically binding to KLLN, this antibody enables precise detection and analysis of the protein in different cell types, making it an essential reagent for cancer research and understanding tumor suppression mechanisms.
KLLN, also known as Kilobase-enhancer factor-like protein 1, plays a crucial role in maintaining genomic stability and preventing abnormal cell growth. Its function as a tumor suppressor suggests its potential as a therapeutic target in cancer treatment and research into mechanisms of tumorigenesis. By investigating the role of KLLN in cancer development, researchers can gain insight into potential strategies for targeted therapies and personalized medicine approaches.
Antibody Name:
KLLN Antibody (PACO19913)
Antibody SKU:
PACO19913
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human KLLN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: MCF7 cells, Hela cells, Primary antibody: PACO19913(KLLN Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53.
Synonyms:
killin, p53-regulated DNA replication inhibitor
UniProt Protein Function:
KILLIN: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single- stranded DNA.Chromosomal Location of Human Ortholog: 10q23Cellular Component: nucleolus; nucleusBiological Process: apoptosis; cell cycle arrestDisease: Cowden Syndrome 4
UniProt Protein Details:
NCBI Summary:
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
