The KLLN Polyclonal Antibody (PAC019912) is a valuable tool for researchers studying the KLLN protein, a tumor suppressor involved in cell cycle regulation and DNA repair. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the KLLN protein, it allows for precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cancer research and molecular biology.
KLLN, also known as KILLIN, plays a crucial role in maintaining genomic stability and preventing the development of cancer. Its function as a tumor suppressor makes it a promising target for research aimed at understanding the mechanisms underlying tumorigenesis and identifying potential therapeutic strategies. Investigating the role of KLLN in cell cycle control and DNA damage response is essential for advancing our knowledge of cancer biology and developing novel treatments for cancer patients.
Antibody Name:
KLLN Antibody (PACO19912)
Antibody SKU:
PACO19912
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human KLLN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO19912(KLLN Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53.
Synonyms:
killin, p53-regulated DNA replication inhibitor
UniProt Protein Function:
KILLIN: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single- stranded DNA.Chromosomal Location of Human Ortholog: 10q23Cellular Component: nucleolus; nucleusBiological Process: apoptosis; cell cycle arrestDisease: Cowden Syndrome 4
UniProt Protein Details:
NCBI Summary:
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
