The KLKB1 Polyclonal Antibody (PAC027825) is a valuable tool for researchers studying KLKB1, a key player in the kallikrein-kinin system that regulates blood coagulation and inflammation. This rabbit-raised antibody has high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the KLKB1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in immunology and cardiovascular research.KLKB1, also known as plasma kallikrein, is a serine protease that plays a crucial role in the activation of the coagulation cascade and the generation of vasoactive peptides involved in inflammation and blood pressure regulation.
Dysregulation of KLKB1 activity has been implicated in various pathologies, including thrombotic disorders, angioedema, and cardiovascular diseases. Therefore, understanding the functions of KLKB1 is essential for the development of targeted therapies aimed at modulating these physiological processes for therapeutic benefits.
Antibody Name:
Klkb1 Antibody (PACO27825)
Antibody SKU:
PACO27825
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Plasma kallikrein protein (391-638AA)
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
NCBI Summary:
serine protease that plays a role in blood coagulation [RGD, Feb 2006]
