Klkb1 Antibody (PACO27821)
- SKU:
- PACO27821
- Product Type:
- Antibody
- Reactivity:
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Klkb1 Antibody (PACO27821)
The KLKB1 Polyclonal Antibody (PAC027821) is a valuable tool for researchers studying the KLKB1 protein, an essential component in the kallikrein-kinin system that plays a key role in inflammation, blood pressure regulation, and coagulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.KLKB1, also known as plasma prekallikrein, is a serine protease that activates several important pathways in the body, including the generation of bradykinin, a potent vasodilator. Dysregulation of KLKB1 has been linked to various diseases, including hereditary angioedema and cardiovascular disorders.
By studying the expression and activity of KLKB1 using this antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.This KLKB1 Polyclonal Antibody is an invaluable tool for investigating the function of KLKB1 in various physiological and pathological processes, making it a valuable addition to studies in cardiovascular biology, inflammation, and coagulation disorders.
| Antibody Name: | Klkb1 Antibody (PACO27821) |
| Antibody SKU: | PACO27821 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Plasma kallikrein protein (391-638AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Klkb1 antibody at 2µg/ml Lane 1: Hela whole cell lysate Lane 2: Rat brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 72 kDa Observed band size: 72 kDa . |
| Synonyms: | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain], Klkb1, Klk3 Pk |
| UniProt Protein Function: | The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| NCBI Summary: | serine protease that plays a role in blood coagulation [RGD, Feb 2006] |
| UniProt Code: | P14272 |
| NCBI GenInfo Identifier: | 125186 |
| NCBI Gene ID: | 25048 |
| NCBI Accession: | P14272.1 |
| UniProt Related Accession: | P14272 |
| Molecular Weight: | 71,274 Da |
| NCBI Full Name: | Plasma kallikrein |
| NCBI Synonym Full Names: | kallikrein B1 |
| NCBI Official Symbol: | Klkb1Â Â |
| NCBI Official Synonym Symbols: | PK; Klk3; Kalp1; KALP15Â Â |
| NCBI Protein Information: | plasma kallikrein |
| UniProt Protein Name: | Plasma kallikrein |
| UniProt Synonym Protein Names: | Fletcher factor; Kininogenin; Plasma prekallikrein |
| Protein Family: | Plasma kallikrein |
| UniProt Gene Name: | Klkb1Â Â |
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