The KLK7 Polyclonal Antibody (PAC027817) is a valuable tool for research involving KLK7, a member of the kallikrein-related peptidase family implicated in various biological processes. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in applications such as Western blotting and immunohistochemistry.KLK7, also known as stratum corneum chymotryptic enzyme, is involved in processes such as skin desquamation, inflammation, and wound healing. Its dysregulation has been linked to skin disorders and certain types of cancer.
The KLK7 Polyclonal Antibody specifically binds to the KLK7 protein, enabling researchers to detect and analyze its expression in different cell types and tissues.With its role in skin biology and disease pathogenesis, KLK7 is an attractive target for studies in dermatology, oncology, and inflammation research. The ability to accurately measure KLK7 levels using this antibody provides valuable insights into its function and potential as a therapeutic target in various clinical conditions.
Antibody Name:
Klk7 Antibody (PACO27817)
Antibody SKU:
PACO27817
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Glandular kallikrein-7, submandibular/renal protein (25-261AA)
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Predominant kallikrein protein in the kidney.
Synonyms:
Glandular kallikrein-7, submandibular/renal (rGK-7) (EC 3.4.21.35) (Esterase B) (Kallikrein-related protein K1) (Proteinase A) (RSKG-7) (Tissue kallikrein), Klk7, Klk-7
UniProt Protein Function:
KLK7: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.21.35Cellular Component: apical part of cell; acrosome; nucleusMolecular Function: serine-type endopeptidase activity; endopeptidase activityBiological Process: positive regulation of acute inflammatory response; positive regulation of apoptosis; positive regulation of cell proliferation; proteolysis; response to nutrient
UniProt Protein Details:
NCBI Summary:
serine protease; involved in processing of bioactive peptides [RGD, Feb 2006]
