The KLK5 Polyclonal Antibody (CAB14863) is a key tool for researchers studying KLK5, a member of the kallikrein-related peptidase family known for their roles in skin physiology and pathology. This specific antibody, generated in rabbits, is highly specific to human KLK5 samples and has been validated for use in Western blot applications.KLK5, also known as hK5 or kallikrein-related peptidase 5, is primarily expressed in the skin and plays a crucial role in maintaining skin barrier function and modulating inflammatory responses. Dysregulation of KLK5 has been linked to various skin conditions, including psoriasis, atopic dermatitis, and skin cancer.
The KLK5 Polyclonal Antibody enables precise detection and analysis of KLK5 protein levels in different cell types, making it an indispensable tool for researchers investigating skin biology, inflammation, and skin disease mechanisms. By studying the function and regulation of KLK5, researchers can gain valuable insights into potential therapeutic targets for skin disorders and develop novel strategies for managing skin-related conditions.
Product Name:
KLK5 Rabbit Polyclonal Antibody
SKU:
CAB14863
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-293 of human KLK5 (NP_001070959.1).
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
25818
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using KLK5 Rabbit pAb (CAB14863) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
