KLK3 Protein Recombinant Protein (RPPB1862)
- SKU:
- RPPB1862
- Product Type:
- Recombinant Protein
- Uniprot:
- P07288
- Research Area:
- Enzymes
Description
| Product Name: | KLK3 Protein Recombinant Protein |
| Product Code: | RPPB1862 |
| Size: | 250ug |
| Target: | KLK3 Protein |
| Synonyms: | Prostate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS, hK3, KLK2A1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in 20mM Tris-HCl, pH 8.0, 150mM NaCl and 3% trehalose. |
| Solubility: | It is recommended to reconstitute the lyophilized Kallikrein-3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized KLK3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Kallikrein-3 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | IVGGWECEKH SQPWQVLVAS RGRAVCGGVL VHPQWVLTAA HCIRNKSVIL LGRHSLFHPE DTGQVFQVSH SFPHPLYDMS LLKNRFLRPG DDSSHDLMLL RLSEPAELTDA VKVMDLPTQE PALGTTCYAS GWGSIEPEEF LTPKKLQCVD LHVISNDVCA QVHPQKVTKF MLCAGRWTGG KSTCSGDSGG PLVCNGVLQG ITSWGSEPCA LPERPSLYTK VVHYRKWIKD TIVANP |
Kallikrein-3 (KLK3) is a part of the kallikrein-related peptidase family. Kallikreins are a subgroup of serine proteases having various physiological functions. Numerous kallikreins take part in carcinogenesis and some may be prospective cancer and other disease biomarkers. Kallikrein-3 is 1 of the 15 kallikrein subfamily members located in a cluster on chromosome 19 and is a protease present in seminal plasma. KLK3 hydrolyzes semenogelin-1 consequently leading to the liquefaction of the seminal coagulum. KLK3 acts normally in the liquefaction of seminal coagulum, probably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of the KLK3 protein, called PSA in the clinical setting, is beneficial in the diagnosis and monitoring of prostatic carcinoma.
Kallikrein-3 Human Recombinant produced in E.Coli is a single, non- glycosylated polypeptide chain containing 237 amino acids and having a molecular mass of 26.1kDa.KLK3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; EC 3.4.21.77; Secreted Chromosomal Location of Human Ortholog: 19q13.41 Cellular Component: extracellular region; nucleus Molecular Function:protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis |
| NCBI Summary: | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07288 |
| NCBI GenInfo Identifier: | 130989 |
| NCBI Gene ID: | 354 |
| NCBI Accession: | P07288.2 |
| UniProt Secondary Accession: | P07288,Q15096, Q16272, Q86TG8, Q8IXI4, C9JXH3, G3V0H4 G3XAE3, |
| UniProt Related Accession: | P07288 |
| Molecular Weight: | 28,741 Da |
| NCBI Full Name: | Prostate-specific antigen |
| NCBI Synonym Full Names: | kallikrein-related peptidase 3 |
| NCBI Official Symbol: | KLK3�� |
| NCBI Official Synonym Symbols: | APS; PSA; hK3; KLK2A1�� |
| NCBI Protein Information: | prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen |
| UniProt Protein Name: | Prostate-specific antigen |
| UniProt Synonym Protein Names: | Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase |
| Protein Family: | Prostate-specific antigen |
| UniProt Gene Name: | KLK3�� |
| UniProt Entry Name: | KLK3_HUMAN |
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