The KLK12 Polyclonal Antibody (CAB16523) is a vital tool for researchers studying KLK12, a member of the kallikrein-related peptidase family involved in various physiological processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the KLK12 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component in studies related to cancer, inflammation, and tissue remodeling.
KLK12, also known as kallikrein-related peptidase 12, plays a crucial role in the modulation of extracellular matrix components, cell migration, and tissue repair. Its dysregulation has been implicated in several disease states, including cancer progression and metastasis. By understanding the functions of KLK12, researchers can gain insights into potential therapeutic targets for diseases characterized by tissue remodeling, making this antibody an invaluable tool in the fields of oncology and regenerative medicine.
Product Name:
KLK12 Rabbit Polyclonal Antibody
SKU:
CAB16523
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-150 of human KLK12 (NP_062544.1).
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
43849
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using KLK12 Rabbit pAb (CAB16523) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
