KLHL3 Rabbit Polyclonal Antibody (CAB13771)
- SKU:
- CAB13771
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | KLHL3 Rabbit Polyclonal Antibody |
SKU: | CAB13771 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human KLHL3 (NP_059111.2). |
Sequence: | MEGE SVKL SSQT LIQA GDDE KNQR TITV NPAH MGKA FKVM NELR SKQL LCDV MIVA EDVE IEAH RVVL AACS PYFC AMFT GDMS ESKA KKIE IKDV DGQT LSKL IDYI YT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PHA2D; KLHL3 |
Positive Sample: | 293T,A-549,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytoskeleton, cytosol. |
Calculated MW: | 65kDa |
Observed MW: | 75kDa |
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 26249 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |