The KLHL14 Polyclonal Antibody (PACO10131) is a vital tool for researchers studying KLHL14, a protein involved in the regulation of cellular processes and functions. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the KLHL14 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for research in the fields of cell biology and molecular biology.KLHL14 is a substrate-specific adaptor of the Cullin3-based E3 ubiquitin ligase complex and is involved in the ubiquitination and degradation of target proteins.
Its role in regulating protein turnover and cellular homeostasis makes it a key player in processes such as cell cycle progression, apoptosis, and signal transduction. Research into the function of KLHL14 is essential for understanding its impact on cellular pathways and developing targeted therapies for diseases related to dysregulated protein degradation.Overall, the KLHL14 Polyclonal Antibody (PACO10131) is a valuable asset for researchers looking to investigate the role of KLHL14 in cellular processes and pathways, providing a reliable tool for studying protein regulation and function in a variety of research settings.
KLHL14: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18q12.1Cellular Component: cell soma; endoplasmic reticulum; neuron projectionMolecular Function: ubiquitin-protein ligase activity
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]
