The KLHL1 Polyclonal Antibody (PACO16592) is a valuable tool for researchers studying the KLHL1 protein, a substrate-specific adaptor of the Cullin3-based E3 ubiquitin ligase complex. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.KLHL1 is known to play a crucial role in protein ubiquitination and degradation, making it a key player in cellular processes such as cell cycle regulation and signaling pathways. By targeting the KLHL1 protein, researchers can gain insights into its function and its involvement in various cellular processes, making it a valuable tool for studies in cell biology, molecular biology, and cancer research.
Understanding the regulatory mechanisms of KLHL1 can provide valuable insights into potential therapeutic targets for diseases associated with dysregulated protein degradation pathways, such as cancer and neurodegenerative disorders. The use of the KLHL1 Polyclonal Antibody in research can aid in uncovering the molecular mechanisms underlying these diseases and ultimately contribute to the development of targeted treatments.
Antibody Name:
KLHL1 Antibody (PACO16592)
Antibody SKU:
PACO16592
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human KLHL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16592(KLHL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16592(KLHL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
KLHL1 (kelch-like protein 1) is a 748 amino acid, protein that is the homolog of the Drosophila kelch protein. Localized to the cytoskeleton, KLHL1 contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers.
