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KLF10/11 Transcription Factor Activity Assay

SKU:
TFAB00195
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
KLF10/11
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet

KLF10/11 Transcription Factor Activity Assay

The KLF10/11 Transcription Factor Activity Assay is a reliable and accurate kit designed to measure the activity of KLF10 and KLF11 transcription factors in various biological samples. These transcription factors play a critical role in regulating gene expression and are involved in numerous cellular processes such as cell growth, differentiation, and apoptosis.This assay kit offers high sensitivity and specificity, ensuring precise and reproducible results for your research needs.

By monitoring the activity of KLF10 and KLF11, researchers can gain insight into the mechanisms underlying various diseases, including cancer, cardiovascular disorders, and inflammatory conditions.Overall, the KLF10/11 Transcription Factor Activity Assay is a valuable tool for investigating the function of these transcription factors and their potential implications in disease pathogenesis and therapeutic development.

Product Name:KLF10/11 Transcription Factor Activity Assay
Product Code:TFAB00195
Target:KLF10/11
Synonyms:EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie KLF10/11 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:KLF10: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 8q22.2

Cellular Component: nucleus

Molecular Function:protein binding; metal ion binding; transcription factor activity

Biological Process: circadian rhythm; transcription, DNA-dependent; positive regulation of osteoclast differentiation; somatic stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; cellular response to starvation; regulation of circadian rhythm; bone mineralization; cell proliferation; negative regulation of cell proliferation; cell-cell signaling; transforming growth factor beta receptor signaling pathway; negative regulation of transcription, DNA-dependent; skeletal development

NCBI Summary:This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q13118
NCBI GenInfo Identifier:11387050
NCBI Gene ID:7071
NCBI Accession:Q13118.1
UniProt Secondary Accession:Q13118,O75411, Q503B2, A8MVH0, B2R794, L0R4P6, L0R679
UniProt Related Accession:Q13118
Molecular Weight:480
NCBI Full Name:Krueppel-like factor 10
NCBI Synonym Full Names:Kruppel-like factor 10
NCBI Official Symbol:KLF10  
NCBI Official Synonym Symbols:EGRA; TIEG; TIEG1; EGR-alpha  
NCBI Protein Information:Krueppel-like factor 10; early growth response-alpha; zinc finger transcription factor TIEG; TGFB-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 1
UniProt Protein Name:Krueppel-like factor 10
UniProt Synonym Protein Names:EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1
Protein Family:Krueppel-like factor
UniProt Gene Name:KLF10  
UniProt Entry Name:KLF10_HUMAN
AntibodiesELISA Kits
Anti-KLF10 Antibody (CAB13180)Human TIEG1 (TGF Beta Inducible Early Response Gene 1) ELISA Kit (HUES02073)
Anti-KLF10 Antibody (CAB6415)
KLF10 Antibody (PACO43465)

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