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KLF1 Polyclonal Antibody

SKU:
CAB24503
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

KLF1 Polyclonal Antibody (CAB24503)

The KLF1 Polyclonal Antibody is a valuable tool for researchers studying the KLF1 protein, a key transcription factor involved in the regulation of erythroid development and differentiation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the KLF1 protein, this antibody allows for the precise detection and analysis of KLF1 expression in a variety of cell types.KLF1, also known as EKLF, plays a crucial role in the development of red blood cells and the maintenance of hemoglobin synthesis.

Dysregulation of KLF1 has been linked to various hematological disorders, making it an important target for research in the fields of hematology and transfusion medicine. Studying the function of KLF1 can provide insights into the pathophysiology of conditions such as thalassemia, sickle cell disease, and other anemias.By using the KLF1 Polyclonal Antibody, researchers can further their understanding of the role of KLF1 in erythropoiesis and hematopoiesis, ultimately leading to the development of new therapeutic interventions for individuals affected by blood disorders.

Product Name:KLF1 Polyclonal Antibody
Product Code:CAB24503
Reactivity:Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Rat liver
Cellular Location:Nucleus

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 211-311 of human KLF1 (NP_006554.1).
Sequence:QYQGH FQLFR GLQGP APGPA TSPSF LSCLG PGTVG TGLGG TAEDP GVIAE TAPSK RGRRS WARKR QAAHT CAHPG CGKSY TKSSH LKAHL RTHTG EKPYA C
Synonyms:KLF1, EKLF, CDAN4, HBFQTL6, INLU, Kruppel like factor 1
Calculated MW:38kDa
Observed MW:38kDa

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