Kinesin light chain 1 (KLC1) Rabbit Polyclonal Antibody (CAB5552)
- SKU:
- CAB5552
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | Kinesin light chain 1 (KLC1) Rabbit Polyclonal Antibody |
SKU: | CAB5552 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 261-560 of human Kinesin light chain 1 (Kinesin light chain 1 (KLC1)) (NP_005543.2). |
Sequence: | LALV YRDQ NKYK DAAN LLND ALAI REKT LGKD HPAV AATL NNLA VLYG KRGK YKEA EPLC KRAL EIRE KVLG KDHP DVAK QLNN LALL CQNQ GKYE EVEY YYQR ALEI YQTK LGPD DPNV AKTK NNLA SCYL KQGK FKQA ETLY KEIL TRAH EREF GSVD DENK PIWM HAEE REEC KGKQ KDGT SFGE YGGW YKAC KVDS PTVT TTLK NLGA LYRR QGKF EAAE TLEE AAMR SRKQ GLDN VHKQ RVAE VLND PENM EKRR SRES LNVD VVKY ESGP DGGE EVSM SVEW NGMR KMKL GLVN |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | KLC; KNS2; KNS2A; Kinesin light chain 1 (KLC1) |
Positive Sample: | SW480,22Rv1,BT-474,MCF7,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell projection, Cytoplasm, Cytoplasmic vesicle, cytoskeleton, growth cone. |
Calculated MW: | 65kDa |
Observed MW: | 60-75kDa |
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.
Purification Method: | Affinity purification |
Gene ID: | 3831 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |