The KLB Polyclonal Antibody (CAB15629) is a key tool for researchers studying KLB, also known as beta-Klotho, a co-receptor for multiple endocrine hormones. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in immunohistochemistry and Western blot applications. By binding specifically to the KLB protein, this antibody allows for precise detection and analysis in various cell types, making it essential for studies in endocrinology and metabolic disorders.KLB is a critical player in metabolic regulation, particularly in energy balance and glucose metabolism.
Its role in mediating the effects of hormones such as FGF21 and FGF19 highlights its importance in research on obesity, diabetes, and other metabolic diseases. Investigating the function of KLB is vital for developing therapeutic interventions that target this pathway for the treatment of metabolic disorders. By using the KLB Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying metabolic regulation and potentially uncover new strategies for managing these conditions.
Product Name:
KLB Rabbit Polyclonal Antibody
SKU:
CAB15629
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1).
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum.
Purification Method:
Affinity purification
Gene ID:
152831
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KLB Rabbit pAb (CAB15629) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
