The CD300A Polyclonal Antibody (CAB0357) is a valuable tool for researchers studying immune regulation and immune response modulation. This antibody, raised in rabbits, targets the CD300A protein, a cell surface molecule that inhibits immune responses. Validated for use in Western blot applications, the CD300A Polyclonal Antibody is highly reactive with human samples, enabling detection and analysis in various cell types.CD300A, also known as an immune inhibitory receptor, plays a critical role in immune homeostasis by regulating inflammation and inhibiting allergic reactions.
Its importance in immune response modulation makes it a promising target for research on cancer, autoimmune disorders, and chronic inflammatory conditions. Researchers can use this antibody to study the activity of CD300A and develop therapies that manipulate immune function for therapeutic purposes.Overall, the CD300A Polyclonal Antibody (CAB0357) is an essential tool for studies in immunology and cancer research, providing valuable insights into the mechanisms of immune regulation and potential therapeutic targets for various diseases.
Product Name:
KIT Rabbit Polyclonal Antibody
SKU:
CAB0357
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-412 of human CD117/c-Kit (NP_000213.1).
Cell membrane, Cytoplasm, Single-pass type I membrane protein.
Calculated MW:
110kDa
Observed MW:
145kDa
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3815
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using CD117/c-Kit Rabbit pAb (CAB0357) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
