KIT Rabbit Polyclonal Antibody (CAB0357)
- SKU:
- CAB0357
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | KIT Rabbit Polyclonal Antibody |
SKU: | CAB0357 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-412 of human CD117/c-Kit (NP_000213.1). |
Sequence: | AVPV VSVS KASY LLRE GEEF TVTC TIKD VSSS VYST WKRE NSQT KLQE KYNS WHHG DFNY ERQA TLTI SSAR VNDS GVFM CYAN NTFG SANV TTTL EVVD KGFI NIFP MINT TVFV NDGE NVDL IVEY EAFP KPEH QQWI YMNR TFTD KWED YPKS ENES NIRY VSEL HLTR LKGT EGGT YTFL VSNS DVNA AIAF NVYV NTK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | PBT; SCFR; C-Kit; CD117; MASTC; CD117/c-Kit |
Positive Sample: | Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Single-pass type I membrane protein. |
Calculated MW: | 110kDa |
Observed MW: | 145kDa |
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3815 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |