KISS1 Polyclonal Antibody (CAB24480)
- SKU:
- CAB24480
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
Product Name: | KISS1 Polyclonal Antibody |
SKU: | CAB24480 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-138 of human KISS1 (NP_002247.3). |
Sequence: | EPLE KVAS VGNS RPTG QQLE SLGL LAPG EQSL PCTE RKPA ATAR LSRR GTSL SPPP ESSG SPQQ PGLS APHS RQIP APQG AVLV QREK DLPN YNWN SFGL RFGK REAA PGNH GRSA GRG |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | KISS1; HH13; KiSS-1; metastasis-suppressor KiSS-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 14kDa |
Observed MW: | Refer to figures |
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
Purification Method: | Affinity purification |
Gene ID: | 3814 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |