The KISS1 Polyclonal Antibody (CAB24480) is a valuable tool for researchers studying KISS1, a protein involved in the regulation of various physiological processes including reproduction, metastasis, and tumor suppression. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.KISS1, also known as metastin, is a promising target for cancer research due to its role in suppressing metastasis and inhibiting tumor growth in various types of cancers. By targeting KISS1, researchers can gain valuable insights into the mechanisms underlying cancer progression and potentially develop novel therapeutic strategies for treating cancer.
The KISS1 Polyclonal Antibody enables precise detection and analysis of KISS1 protein levels in different cell types, offering researchers a valuable tool for studying the molecular mechanisms underlying reproductive disorders, cancer progression, and other diseases. By understanding the function of KISS1, researchers can uncover new therapeutic targets and develop innovative treatments for diseases associated with aberrant KISS1 signaling.
Product Name:
KISS1 Polyclonal Antibody
SKU:
CAB24480
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-138 of human KISS1 (NP_002247.3).
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
Purification Method:
Affinity purification
Gene ID:
3814
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human placenta using KISS1 Rabbit pAb (CAB24480) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
