The KiSS-1 Receptor Polyclonal Antibody (CAB2967) is a valuable tool for researchers studying the KiSS-1 receptor, a G-protein coupled receptor involved in the regulation of metastasis and tumor growth in various cancers. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications.The KiSS-1 receptor, also known as GPR54, plays a critical role in the metastatic cascade by inhibiting tumor cell invasion and migration. Its dysregulation has been linked to increased tumor aggressiveness and poor prognosis in cancer patients.
By targeting the KiSS-1 receptor, researchers can gain insight into the mechanisms driving tumor progression and potentially develop novel therapeutic strategies to inhibit metastasis.This antibody enables the detection and analysis of KiSS-1 receptor expression in various cell types, making it suitable for studies in cancer biology and metastasis research. Understanding the role of the KiSS-1 receptor in tumor progression is essential for the development of targeted therapies that can effectively inhibit metastasis and improve patient outcomes.
Product Name:
KISS1R Rabbit Polyclonal Antibody
SKU:
CAB2967
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human KISS1R (NP_115940.2).
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty.
Purification Method:
Affinity purification
Gene ID:
84634
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KISS1R Rabbit pAb (CAB2967) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
