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KIRREL3 Antibody (PACO60216)

SKU:
PACO60216
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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KIRREL3 Antibody (PACO60216)

The Kirrel3 Polyclonal Antibody (PACO60216) is a valuable tool for researchers studying Kirrel3, a key protein involved in cell-cell adhesion and signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting Kirrel3 in various experimental settings, including Western blot analyses. By targeting the Kirrel3 protein, researchers can gain insights into its role in cell communication and its potential implications in developmental biology and neurological diseases.Kirrel3, also known as Nephrin-like protein 2, is recognized for its involvement in synaptic plasticity and neuronal development.

Its expression in the brain suggests a critical function in neural connectivity and communication, making it a promising target for studies on neurodevelopmental disorders and neurological conditions. By utilizing the Kirrel3 Polyclonal Antibody, researchers can explore the functional significance of Kirrel3 in various biological processes and gain a deeper understanding of its potential therapeutic implications.

Antibody Name:KIRREL3 Antibody (PACO60216)
Antibody SKU:PACO60216
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Kin of IRRE-like protein 3 protein (200-343AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescence staining of HepG2 cells with PACO60216 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
Synonyms:Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3], KIRREL3, KIAA1867 NEPH2
UniProt Protein Function:KIRREL3: Could be involved in the hematopoietic supportive capacity of stroma cells. A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q24Cellular Component: axon; plasma membrane; extracellular region; integral to membrane; dendritic shaftMolecular Function: protein bindingBiological Process: pontine nucleus development; neuron migration; hemopoiesis; neurite morphogenesisDisease: Mental Retardation, Autosomal Dominant 4
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:Q8IZU9
NCBI GenInfo Identifier:26006461
NCBI Gene ID:84623
NCBI Accession:NP_115920
UniProt Secondary Accession:Q8IZU9,Q3MIJ7, Q6UWJ9, Q6UWL5, Q96JG0
UniProt Related Accession:Q8IZU9
Molecular Weight:Predicted: 64; 84 kDaObserved: 60 kDa
NCBI Full Name:kin of IRRE-like protein 3 isoform 1
NCBI Synonym Full Names:kin of IRRE like 3 (Drosophila)
NCBI Official Symbol:KIRREL3  
NCBI Official Synonym Symbols:MRD4; KIRRE; NEPH2; PRO4502  
NCBI Protein Information:kin of IRRE-like protein 3; nephrin-like 2; nephrin-like protein 2; kin of irregular chiasm-like protein 3
UniProt Protein Name:Kin of IRRE-like protein 3
UniProt Synonym Protein Names:Kin of irregular chiasm-like protein 3; Nephrin-like protein 2
Protein Family:
UniProt Gene Name:KIRREL3  
UniProt Entry Name:KIRR3_HUMAN
Antibodies
KIRREL3 Antibody (PACO10115)
Secondary Antibody
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