The Kirrel Polyclonal Antibody (CAB14283) is a valuable tool for researchers studying Kirrel, a key protein involved in cell adhesion and synaptic function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in immunohistochemistry and immunofluorescence applications. By specifically binding to Kirrel protein, this antibody enables precise detection and analysis in various tissue types, making it a valuable asset for studies in neuroscience and developmental biology.
Kirrel, also known as Kin of IRRE-like protein, plays a crucial role in mediating cell-cell interactions and synaptic connectivity in the nervous system. Its involvement in synaptic adhesion and signaling makes it a promising target for research on neurodevelopmental disorders, such as autism and schizophrenia. By elucidating the functions of Kirrel, researchers can gain insights into the mechanisms underlying neurological conditions and potentially develop new therapeutic strategies for addressing them.
Product Name:
KIRREL Rabbit Polyclonal Antibody
SKU:
CAB14283
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-200 of human KIRREL (NP_060710.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
84kDa
Observed MW:
83kDa
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).
Purification Method:
Affinity purification
Gene ID:
55243
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KIRREL Rabbit pAb (CAB14283) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
