KIR3DS1 Rabbit Polyclonal Antibody (CAB9936)
- SKU:
- CAB9936
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | KIR3DS1 Rabbit Polyclonal Antibody |
SKU: | CAB9936 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human KIR3DS1 (NP_001077008.1). |
Sequence: | FNMS PVTT AHAG NYTC RGSH PHSP TGWS APSN PMVI MVTG NHRK PSLL AHPG PLVK SGER VILQ CWSD IMFE HFFL HKEW ISKD PSRL VGQI HDGV SKAN FSIG SMMR ALAG TYRC YGSV THTP YQLS APSD PLDI VVTG LYEK PSLS AQPG PKVQ AGES VTLS CSSR SSYD MYHL SREG GAHE RRLP AVRK VNRT FQAD FPLG PATH GGTY RCFG SFRH SPYE WSDP SDPL LVSV TGNP SSSW PSPT EPSS KSGN LRHL H |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM; KIR3DS1 |
Positive Sample: | Jurkat,A-549,THP-1,BT-474,B cells,Mouse liver,Mouse kidney,Mouse pancreas,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 42kDa |
Observed MW: | 60kDa |
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3813 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |