The KIR3DL3 Polyclonal Antibody (CAB10064) is a valuable tool for researchers studying the KIR3DL3 protein, a member of the killer cell immunoglobulin-like receptor (KIR) family. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the KIR3DL3 protein, this antibody enables the detection and analysis of KIR3DL3 expression in various cell types, making it an ideal tool for immunology and cancer research studies.KIR3DL3 is known to play a crucial role in immune regulation, particularly in modulating the functions of natural killer (NK) cells and T cells.
Its involvement in immune response modulation makes it a promising target for research into diseases such as cancer, infectious diseases, and autoimmune disorders. Understanding the role of KIR3DL3 can provide insights into immune mechanisms and aid in the development of novel therapeutic strategies to manipulate immune responses in different disease contexts.Overall, the KIR3DL3 Polyclonal Antibody (CAB10064) offers researchers a reliable and specific tool to study the KIR3DL3 protein and its functions in immune regulation and disease pathogenesis.
Product Name:
KIR3DL3 Rabbit Polyclonal Antibody
SKU:
CAB10064
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-322 of human KIR3DL3 (NP_703144.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
45kDa
Observed MW:
45kDa
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.
Purification Method:
Affinity purification
Gene ID:
115653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KIR3DL3 Rabbit pAb (CAB10064) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
