KIR3DL3 Rabbit Polyclonal Antibody (CAB10064)
- SKU:
- CAB10064
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | KIR3DL3 Rabbit Polyclonal Antibody |
SKU: | CAB10064 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-322 of human KIR3DL3 (NP_703144.3). |
Sequence: | QDKP FLSA WPGT VVSE GQHV TLQC RSRL GFNE FSLS KEDG MPVP ELYN RIFR NSFL MGPV TPAH AGTY RCCS SHPH SPTG WSAP SNPV VIMV TGVH RKPS LLAH PGPL VKSG ETVI LQCW SDVR FERF LLHR EGIT EDPL RLVG QLHD AGSQ VNYS MGPM TPAL AGTY RCFG SVTH LPYE LSAP SDPL DIVV VGLY GKPS LSAQ PGPT VQAG ENVT LSCS SRSL FDIY HLSR EAEA GELR LTAV LRVN GTFQ ANFP LGPV THGG NYRC FGSF RALP HAWS DPSD PLPV SVTG NSRN L |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | KIR44; KIRC1; CD158Z; KIR3DL7; KIR2DL5B; KIR3DL3 |
Positive Sample: | HepG2,SGC-7901 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.
Purification Method: | Affinity purification |
Gene ID: | 115653 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |