The KIR3DL1 Polyclonal Antibody (CAB1617) is a vital tool for researchers studying KIR3DL1, a killer cell immunoglobulin-like receptor involved in regulating the function of natural killer cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the KIR3DL1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an indispensable asset for investigations in immunology and cancer research.
KIR3DL1 is a key player in immune surveillance and response, exerting crucial functions in recognizing and targeting infected or abnormal cells. Its role in natural killer cell activation and inhibitory signaling pathways underscores its significance in immune regulation and anti-tumor immunity. Studies on KIR3DL1 provide valuable insights into immune responses against infections, cancer progression, and autoimmune diseases, paving the way for the development of targeted immunotherapies and treatment strategies.
Product Name:
KIR3DL1 Rabbit Polyclonal Antibody
SKU:
CAB1617
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-222 of human KIR3DL1 (NP_037421.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
49kDa
Observed MW:
48kDa
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Purification Method:
Affinity purification
Gene ID:
3811
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KIR3DL1 antibody (CAB1617) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
