The KIR2DS1 Antibody (PAC035778) is a highly specific and sensitive tool designed for research involving the KIR2DS1 protein, a member of the killer cell immunoglobulin-like receptor (KIR) family known for its role in immune regulation and response. Raised in rabbits, this polyclonal antibody is optimized for detection and analysis of KIR2DS1 in human samples, making it a valuable asset for immunology and cancer research studies.KIR2DS1 is a key player in immune activation and has been linked to various diseases, including cancer and autoimmune disorders. By targeting and binding to the KIR2DS1 protein, this antibody allows for precise detection and characterization of its function in different cell types.
This enables researchers to better understand the role of KIR2DS1 in immune response modulation and potential therapeutic interventions for diseases characterized by dysregulated immune function.With its high reactivity and specificity, the KIR2DS1 Antibody (PAC035778) is a reliable tool for researchers looking to deepen their understanding of immune regulation and its implications for various disease states. Its validation for use in Western blot applications further enhances its utility in experimental settings, making it an essential component for investigations into the complex mechanisms of immune system function.
Antibody Name:
KIR2DS1 Antibody (PACO35778)
Antibody SKU:
PACO35778
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Killer cell immunoglobulin-like receptor 2DS1 protein (22-245AA)
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Synonyms:
Killer cell immunoglobulin-like receptor 2DS1 (CD158 antigen-like family member H) (MHC class I NK cell receptor Eb6 ActI) (CD antigen CD158h), KIR2DS1, CD158H
UniProt Protein Function:
KIR2DS1: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamilyChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membraneBiological Process: innate immune response; regulation of immune response
UniProt Protein Details:
NCBI Summary:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
