The KIR2DL5A/KIR2DL5B Antibody (PAC007365) is a highly specific polyclonal antibody designed for research involving the Killer cell immunoglobulin-like receptor 2DL5A and Killer cell immunoglobulin-like receptor 2DL5B proteins. These receptors are part of the killer cell immunoglobulin-like receptor (KIR) family, which play a key role in regulating the activity of natural killer (NK) cells in the immune system.Raised in rabbits, this antibody is optimized for use in Western blot applications and is highly reactive with human samples. It specifically targets the KIR2DL5A and KIR2DL5B proteins, allowing for accurate detection and analysis in a variety of cell types. This makes it an ideal tool for researchers studying immunology, particularly in the context of infectious diseases, cancer, and autoimmune disorders.
The KIR2DL5A and KIR2DL5B proteins are important immune regulators that help modulate the activity of NK cells, which play a crucial role in immune surveillance and defense against infected or abnormal cells. Understanding the function of these receptors is essential for unraveling the complexities of immune responses and developing new therapies for a range of diseases. The KIR2DL5A/KIR2DL5B Antibody is a valuable resource for researchers working to uncover the role of KIR receptors in immune regulation and disease pathogenesis.
Antibody Name:
KIR2DL5A/KIR2DL5B Antibody (PACO07365)
Antibody SKU:
PACO07365
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:10000-1:20000, IHC-p:1:50-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide from human protein at AA range: 121-170
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200.
UniProt Protein Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
UniProt Protein Details:
NCBI Summary:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
