The KIR2DL4 Polyclonal Antibody (CAB12836) is a valuable tool for researchers studying the function of KIR2DL4, a killer cell immunoglobulin-like receptor involved in immune response regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding specifically to the KIR2DL4 protein, this antibody allows for accurate detection and analysis in various cell types, making it a versatile option for studies in immunology and cancer research.KIR2DL4 is known for its role in immune modulation, particularly in regulating immune responses and promoting immune tolerance.
Its involvement in immune function makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By gaining a better understanding of KIR2DL4 activity, researchers can explore potential therapeutic strategies that manipulate immune responses in these disease contexts.Overall, the KIR2DL4 Polyclonal Antibody (CAB12836) offers a reliable tool for investigating the function and significance of KIR2DL4 in various research applications, ultimately advancing our knowledge of immune regulation and its implications in disease.
Product Name:
KIR2DL4 Rabbit Polyclonal Antibody
SKU:
CAB12836
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-242 of human KIR2DL4 (NP_002246.5).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
41kDa
Observed MW:
51kDa
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly.
Purification Method:
Affinity purification
Gene ID:
3805
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293F cells transfected with KIR2DL4 using KIR2DL4 Rabbit pAb (CAB12836) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
