KIR2DL3/KIR2DS2 Antibody (PACO02093)
- SKU:
- PACO02093
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KIR2DL3/KIR2DS2 Antibody (PACO02093)
The KIR2DL3/KIR2DS2 Antibody (PAC02093) is a polyclonal antibody designed for research involving the KIR2DL3 and KIR2DS2 proteins, which are members of the killer cell immunoglobulin-like receptor (KIR) family. These proteins play a crucial role in regulating the activity of natural killer (NK) cells in the immune system.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in various research applications, including Western blotting and immunohistochemistry. By binding to the KIR2DL3 and KIR2DS2 proteins, this antibody enables the detection and analysis of these important immune regulatory molecules in different cell types.
The KIR2DL3/KIR2DS2 Antibody (PAC02093) is a valuable tool for researchers investigating the role of KIR receptors in immune response modulation, particularly in the context of infectious diseases, autoimmune disorders, and cancer. By studying the function and expression of KIR2DL3 and KIR2DS2, scientists can gain insights into the mechanisms of immune recognition and regulation, ultimately leading to the development of novel therapeutic strategies targeting these receptors.
| Antibody Name: | KIR2DL3/KIR2DS2 Antibody |
| Antibody SKU: | PACO02093 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human CD158b2/j. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | KIR2DL3; CD158B2; KIRCL23; NKAT2; Killer cell immunoglobulin-like receptor 2DL3; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b |
| UniProt Protein Function: | KIR2DL3: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:protein binding; receptor activity; antigen binding Biological Process: regulation of immune response; immune response |
| NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43628 |
| NCBI GenInfo Identifier: | 1171727 |
| NCBI Gene ID: | 3804 |
| NCBI Accession: | P43628.1 |
| UniProt Related Accession: | P43628 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | Killer cell immunoglobulin-like receptor 2DL3 |
| NCBI Synonym Full Names: | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 |
| NCBI Official Symbol: | KIR2DL3Â Â |
| NCBI Official Synonym Symbols: | p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GBÂ Â |
| NCBI Protein Information: | killer cell immunoglobulin-like receptor 2DL3 |
| UniProt Protein Name: | Killer cell immunoglobulin-like receptor 2DL3 |
| UniProt Synonym Protein Names: | CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b; Natural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD_antigen: CD158b2 |
| Protein Family: | Killer cell immunoglobulin-like receptor |
| UniProt Gene Name: | KIR2DL3Â Â |
| UniProt Entry Name: | KI2L3_HUMAN |
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