Anti-KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody (PACO15953)

Antibody Name:	KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody (PACO15953)
Antibody SKU:	PACO15953
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:50-1:100
Species Reactivity:	Human
Immunogen:	Fusion protein of human KIR2DL3/1/4/S4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15953(KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15953(KIR2DL3/KIR2DL1/KIR2DL4/KIR2DS4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain.

Synonyms:

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3/1/4/ short cytoplasmic tail, 4

UniProt Protein Function:	KIR2DL3: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4 Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:protein binding; receptor activity; antigen binding Biological Process: regulation of immune response; immune response
NCBI Summary:	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
UniProt Code:	P43628
NCBI GenInfo Identifier:	1171727
NCBI Gene ID:	3804
NCBI Accession:	P43628.1
UniProt Related Accession:	P43628
Molecular Weight:	45kDa
NCBI Full Name:	Killer cell immunoglobulin-like receptor 2DL3
NCBI Synonym Full Names:	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
NCBI Official Symbol:	KIR2DL3
NCBI Official Synonym Symbols:	p58; NKAT; GL183; NKAT2; CD158b; KIR2DL; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB
NCBI Protein Information:	killer cell immunoglobulin-like receptor 2DL3
UniProt Protein Name:	Killer cell immunoglobulin-like receptor 2DL3
UniProt Synonym Protein Names:	CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2b; Natural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD_antigen: CD158b2
Protein Family:	Killer cell immunoglobulin-like receptor
UniProt Gene Name:	KIR2DL3
UniProt Entry Name:	KI2L3_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)