The Kininogen-1 Rabbit Monoclonal Antibody is a valuable tool for research involving kininogen-1, a protein involved in the regulation of inflammation and blood clotting. This antibody, produced in rabbits, is highly specific for kininogen-1 and is validated for use in various applications such as Western blotting and immunohistochemistry.Kininogen-1 plays a crucial role in the kinin-kallikrein system, which is involved in the regulation of blood pressure, inflammation, and pain sensation. Dysregulation of this system has been linked to various diseases, including cardiovascular disease, inflammation, and cancer.
By using the Kininogen-1 Rabbit Monoclonal Antibody, researchers can study the expression and function of kininogen-1 in different cell types and tissues, providing insights into its role in health and disease.Overall, the Kininogen-1 Rabbit Monoclonal Antibody is a valuable tool for researchers interested in studying the kinin-kallikrein system and its implications in various pathological conditions. Its high specificity and reliability make it an essential reagent for studies in immunology, oncology, and cardiovascular research.
Product Name:
Kininogen 1 (KNG1) Rabbit Monoclonal Antibody
SKU:
CAB11638
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 545-644 of human Kininogen 1 (KNG1) (NP_001095886.1).
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3827
Clone Number:
ARC0653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Kininogen 1 (KNG1) (KNG1) Rabbit mAb (CAB11638) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
