Kininogen 1 (KNG1) Rabbit Monoclonal Antibody (CAB11638)
- SKU:
- CAB11638
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | Kininogen 1 (KNG1) Rabbit Monoclonal Antibody |
SKU: | CAB11638 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 545-644 of human Kininogen 1 (KNG1) (NP_001095886.1). |
Sequence: | PTPI PSLA KPGV TVTF SDFQ DSDL IATM MPPI SPAP IQSD DDWI PDIQ IDPN GLSF NPIS DFPD TTSP KCPG RPWK SVSE INPT TQMK ESYY FDLT DGLS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | BK; HK; BDK; KNG; HAE6; HMWK; Kininogen 1 (KNG1) |
Positive Sample: | 293T, HepG2, Mouse kidney, Rat liver, Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space |
Calculated MW: | 44kDa/48kDa/72kDa |
Observed MW: | 46kDa |
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3827 |
Clone Number: | ARC0653 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |