Kininogen 1 (KNG1) Rabbit Polyclonal Antibody (CAB1670)
- SKU:
- CAB1670
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | Kininogen 1 (KNG1) Rabbit Polyclonal Antibody |
SKU: | CAB1670 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human Kininogen 1 (KNG1) (NP_000884.1). |
Sequence: | PIST QSPD LEPI LRHG IQYF NNNT QHSS LFML NEVK RAQR QVVA GLNF RITY SIVQ TNCS KENF LFLT PDCK SLWN GDTG ECTD NAYI DIQL RIAS FSQN CDIY PGKD FVQP PTKI CVGC PRDI PTNS PELE ETLT HTIT KLNA ENNA TFYF KIDN VKKA RVQV VAGK KYFI DFVA RETT CSKE SNEE LTES CETK KLGQ SLDC NAEV YVVP WEKK IYPT VNCQ PLGM ISLM KRPP GFSP FRSS RIGE IKEE TTSH LRSC EYKG RPPK AGAE PASE REVS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | BK; HK; BDK; KNG; HAE6; HMWK; Kininogen 1 (KNG1) |
Positive Sample: | Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 72kDa |
Observed MW: | 72kDa |
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 3827 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |