Anti-KTN1 Antibody (CAB5879)
- SKU:
- CAB5879
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-KTN1 Antibody (CAB5879)
The Kinectin Polyclonal Antibody (CAB5879) is a valuable tool for researchers studying the role of kinectin, a protein involved in intracellular transport and cellular organization. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to kinectin, this antibody allows for the detection and analysis of kinectin expression in various cell types.Kinectin is known for its involvement in the transport of organelles and vesicles within cells, making it essential for processes such as cell division and protein trafficking.
Research on kinectin has implications for understanding cellular dynamics and mechanisms underlying various diseases, including neurodegenerative disorders and cancer.The Kinectin Polyclonal Antibody (CAB5879) provides a valuable tool for investigating the function of kinectin in cellular processes and disease pathophysiology. Its specificity and reactivity make it an essential reagent for researchers in cell biology, molecular biology, and biomedical sciences.
| Antibody Name: | Anti-KTN1 Antibody |
| Antibody SKU: | CAB5879 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KTN1 (NP_001072989.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | A-549, A673, HeLa, MCF7 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KTN1 (NP_001072989.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEFY ESAY FIVL IPSI VITV IFLF FWLF MKET LYDE VLAK QKRE QKLI PTKT DKKK AEKK KNKK KEIQ NGNL HESD SESV PRDF KLSD ALAV EDDQ VAPV |
| Gene ID: | 3895 |
| Uniprot: | Q86UP2 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type II membrane protein |
| Calculated MW: | 149kDa/150kDa/152kDa/156kDa |
| Observed MW: | 166kDa |
| Synonyms: | KTN1, CG1, KNT, MU-RMS-40.19, kinectin |
| Background: | This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. |
| UniProt Protein Function: | KTN1: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms. High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon. Belongs to the kinectin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q22.3 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; integral to plasma membrane; membrane Molecular Function:cadherin binding; kinesin binding; protein binding; RNA binding |
| NCBI Summary: | This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q86UP2 |
| NCBI GenInfo Identifier: | 34098465 |
| NCBI Gene ID: | 3895 |
| NCBI Accession: | Q86UP2.1 |
| UniProt Secondary Accession: | Q86UP2,Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57 B4DZ88, |
| UniProt Related Accession: | Q86UP2 |
| Molecular Weight: | 156kDa |
| NCBI Full Name: | Kinectin |
| NCBI Synonym Full Names: | kinectin 1 |
| NCBI Official Symbol: | KTN1Â Â |
| NCBI Official Synonym Symbols: | CG1; KNT; MU-RMS-40.19Â Â |
| NCBI Protein Information: | kinectin |
| UniProt Protein Name: | Kinectin |
| UniProt Synonym Protein Names: | CG-1 antigen; Kinesin receptor |
| Protein Family: | Kinectin |
| UniProt Gene Name: | KTN1Â Â |
 | Western blot analysis of extracts of various cell lines, using KTN1 antibody (CAB5879) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using KTN1 antibody (CAB5879) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using KTN1 antibody (CAB5879) at dilution of 1:100 (40x lens). |
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