KIFAP3 Rabbit Monoclonal Antibody (CAB5216)
- SKU:
- CAB5216
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | KIFAP3 Rabbit Monoclonal Antibody |
SKU: | CAB5216 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 675-792 of human KIFAP3 (Q92845). |
Sequence: | KFRW HNSQ WLEM VESR QMDE SEQY LYGD DRIE PYIH EGDI LERP DLFY NSDG LIAS EGAI SPDF FNDY HLQN GDVV GQHS FPGS LGMD GFGQ PVGI LGRP ATAY GFRP DEPY YYGY GS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1; KIFAP3 |
Positive Sample: | HeLa,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | axoneme, centrosome, ciliary basal body, condensed nuclear chromosome, cytosol, endoplasmic reticulum, Golgi apparatus, microtubule cytoskeleton, photoreceptor inner segment, photoreceptor outer segment |
Calculated MW: | 91kDa |
Observed MW: | 100kDa |
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 22920 |
Clone Number: | ARC1211 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |