KIFAP3 Rabbit Polyclonal Antibody (CAB4518)
- SKU:
- CAB4518
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- KIFAP3
- FLA3
- KAP-1
- KAP-3
- KAP3
- SMAP
- Smg-GDS
- dJ190I16.1
- Research Area:
- Cell Biology
Description
Product Name: | KIFAP3 Rabbit Polyclonal Antibody |
SKU: | CAB4518 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human KIFAP3 (NP_055785.2). |
Sequence: | MQGE DARY LKRK VKGG NIDV HPSE KALI VHYE VEAT ILGE MGDP MLGE RKEC QKII RLKS LNAN TDIT SLAR KVVE ECKL IHPS KLNE VEQL LYYL QNRR DSLS GKEK KEKS SKPK DPPP FEGM EIDE VANI NDMD EYIE LLYE DIPD KVRG SALI LQLA RNPD NLEE LLLN ETAL GALA RVLR EDWK QSVE LATN IIYI |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1; KIFAP3 |
Positive Sample: | LO2,SH-SY5Y,Mouse brain,Mouse testis,Mouse lung,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | axoneme, centrosome, ciliary basal body, condensed nuclear chromosome, cytosol, endoplasmic reticulum, Golgi apparatus, microtubule cytoskeleton, photoreceptor inner segment, photoreceptor outer segment |
Calculated MW: | 91kDa |
Observed MW: | 110kDa |
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 22920 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |