The KIF7 Polyclonal Antibody (CAB15581) is a valuable tool for researchers studying the KIF7 protein, an important regulator of cell division and development. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KIF7 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for studies in developmental biology and cancer research.KIF7 is a member of the kinesin superfamily of motor proteins and is involved in the regulation of key cellular processes such as cell division, cell signaling, and cilia formation.
Dysregulation of KIF7 has been linked to developmental disorders and cancer, making it a promising target for therapeutic intervention. By understanding the function and activity of KIF7, researchers can gain valuable insights into the underlying mechanisms of disease and potentially develop new treatment strategies.Overall, the KIF7 Polyclonal Antibody (CAB15581) is a reliable tool for investigating the role of KIF7 in various cellular processes and disease conditions. Its high specificity and sensitivity make it a valuable asset for researchers in the fields of cell biology, developmental biology, and oncology.
Product Name:
KIF7 Rabbit Polyclonal Antibody
SKU:
CAB15581
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1044-1343 of human KIF7 (NP_940927.2).
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
Purification Method:
Affinity purification
Gene ID:
374654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KIF7 Rabbit pAb (CAB15581) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
