The KIF4A Polyclonal Antibody (CAB10193) is designed for research involving KIF4A, a kinesin family member protein known for its role in mitotic spindle dynamics and chromosome segregation. The antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot and immunohistochemistry applications. It specifically binds to the KIF4A protein, enabling accurate detection and analysis in various cell types and tissues.KIF4A is essential for proper cell division and genome stability, making it a key player in cell proliferation and development. Its dysregulation has been linked to diseases such as cancer, where abnormal cell division processes contribute to tumor growth and progression.
Understanding the function of KIF4A is crucial for unraveling its role in disease pathology and developing targeted therapies.Overall, the KIF4A Polyclonal Antibody is a valuable tool for researchers studying cell division, mitosis, and the role of kinesin proteins in health and disease. Its applications in both basic science and translational research make it an essential component in advancing our understanding of cellular processes and potential therapeutic targets.
Product Name:
KIF4A Rabbit Polyclonal Antibody
SKU:
CAB10193
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 870-1080 of human KIF4A (NP_036442.3).
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.
Purification Method:
Affinity purification
Gene ID:
24137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using KIF4A Rabbit pAb (CAB10193) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
